Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes.
نویسندگان
چکیده
We have developed hybrid P450 BM3 enzymes consisting of a Ru(II)-diimine photosensitizer covalently attached to non-native single cysteine residues of P450 BM3 heme domain mutants. These enzymes are capable, upon light activation, of selectively hydroxylating lauric acid with 40 times higher total turnover numbers compared to the peroxide shunt.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 47 43 شماره
صفحات -
تاریخ انتشار 2011